Cwnchy
2021-01-29T01:30:58+00:00
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实锤了？新冠病毒可能真的会影响男性生殖能力！[流泪]记得我们之前有关新冠的非典型症状的一个微头条里，备注过一个彩蛋，就是新冠病毒可能喜欢攻击男同胞的睾丸，之前这个问题经过了不少的学术争论，甚至出现过辟谣等情况，毕竟人类对于繁衍后代的问题格外重视，斩钉截铁的这么说容易引起恐慌(但是对于特别不听话的某些国家，这样吓唬一下也许能有助于防疫.....)之前有研究表明，新冠病毒可以在很大程度上通过细胞因子风暴而破坏男性生殖系统。但是对于新冠病毒是否可以直接感染人类睾丸并进入精液尚存争议。 近日，我国科学家发表在 Reproduction杂志的一项研究表明，COVID-19可能会引起睾丸损伤，男性生殖能力大幅下降。研究人员分析了84名新冠男性患者的精液，每10天对他们精液进行分析发现，患者精子细胞的炎症和氧化应激显着增加，且精子浓度，活动性和形状也受到不同程度的影响。研究人员进一步分析了影响男性生殖的可能机制，主要有直接病毒侵袭生殖细胞并通过性传播病毒；继发性病毒感染引起的炎症反应，严重影响睾丸。此外，另外可能影响的因素是用于治疗病毒感染的药物，也有可能对男性生育力产生不利影响。 所以，如果感染过新冠病毒后，恢复期的男性如果计划生育，必须去评估精子质量，咨询医生，因为新冠对人类生殖系统的影响还处于初级阶段，故应谨慎对待疾病痊愈后的生育。
文献地址
[url]https://rep.bioscientifica.com/view/journals/rep/161/2/REP-20-0523.xml[/url]
Abstract
Invasion or damage of the male reproductive system is one of the reported outcomes of viral infection. Current studies have documented that SARS-CoV-2, which causes COVID-19, can damage the male reproductive system in large part by inflammatory damage caused by a cytokine storm. However, whether SARS-CoV-2 can infect the human testis directly and enter semen is controversial. Other adverse effects of SARS-CoV-2 on male reproduction are also of concern and require comprehensive evaluation. Here, we analyze the invasiveness of SARS-CoV-2 in the testis and examine reported mechanisms by which SARS-CoV-2 interferes with male reproduction. Long-term implications of SARS-CoV-2 infection on male reproduction are also discussed. It should be emphasized that although COVID-19 may induce testicular damage, a substantial decrease in male reproductive capacity awaits clinical evidence. We propose that there is an urgent need to track male COVID-19 patients during their recovery. The development of suitable experimental models, including human reproductive organoids, will be valuable to further investigate the viral impact on reproduction for current and future pandemics.
实锤了？新冠病毒可能真的会影响男性生殖能力！[流泪]记得我们之前有关新冠的非典型症状的一个微头条里，备注过一个彩蛋，就是新冠病毒可能喜欢攻击男同胞的睾丸，之前这个问题经过了不少的学术争论，甚至出现过辟谣等情况，毕竟人类对于繁衍后代的问题格外重视，斩钉截铁的这么说容易引起恐慌(但是对于特别不听话的某些国家，这样吓唬一下也许能有助于防疫.....)之前有研究表明，新冠病毒可以在很大程度上通过细胞因子风暴而破坏男性生殖系统。但是对于新冠病毒是否可以直接感染人类睾丸并进入精液尚存争议。 近日，我国科学家发表在 Reproduction杂志的一项研究表明，COVID-19可能会引起睾丸损伤，男性生殖能力大幅下降。研究人员分析了84名新冠男性患者的精液，每10天对他们精液进行分析发现，患者精子细胞的炎症和氧化应激显着增加，且精子浓度，活动性和形状也受到不同程度的影响。研究人员进一步分析了影响男性生殖的可能机制，主要有直接病毒侵袭生殖细胞并通过性传播病毒；继发性病毒感染引起的炎症反应，严重影响睾丸。此外，另外可能影响的因素是用于治疗病毒感染的药物，也有可能对男性生育力产生不利影响。 所以，如果感染过新冠病毒后，恢复期的男性如果计划生育，必须去评估精子质量，咨询医生，因为新冠对人类生殖系统的影响还处于初级阶段，故应谨慎对待疾病痊愈后的生育。
文献地址
[url]https://rep.bioscientifica.com/view/journals/rep/161/2/REP-20-0523.xml[/url]
Abstract
Invasion or damage of the male reproductive system is one of the reported outcomes of viral infection. Current studies have documented that SARS-CoV-2, which causes COVID-19, can damage the male reproductive system in large part by inflammatory damage caused by a cytokine storm. However, whether SARS-CoV-2 can infect the human testis directly and enter semen is controversial. Other adverse effects of SARS-CoV-2 on male reproduction are also of concern and require comprehensive evaluation. Here, we analyze the invasiveness of SARS-CoV-2 in the testis and examine reported mechanisms by which SARS-CoV-2 interferes with male reproduction. Long-term implications of SARS-CoV-2 infection on male reproduction are also discussed. It should be emphasized that although COVID-19 may induce testicular damage, a substantial decrease in male reproductive capacity awaits clinical evidence. We propose that there is an urgent need to track male COVID-19 patients during their recovery. The development of suitable experimental models, including human reproductive organoids, will be valuable to further investigate the viral impact on reproduction for current and future pandemics.